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タイトル: Repeated administrations of concanavalin A induce Th1 to Th2 cytokine shift and tolerance against liver injury in mice
著者: Tamaki, Yosui
Yoneda, Masashi
Sato, Keisuke
Yokohama, Shiro
Haneda, Masakazu
Nakamura, Kimihide
中村, 公英
キーワード: Concanavalin A
Tolerance
Cytokine
Liver injury
T cell
発行日: Aug-2006
出版者: ELSEVIER
誌名: Hepatology research
巻: 35
号: 4
開始ページ: 242-249
抄録: The intravenous injection of concanavalin A (Con A) activates T cells and induces cytokine dependent liver injury in mice. However, the effect of repeated administrations of Con A has not been fully investigated. Female BALB/c mice were intravenously injected with Con A (20 mg/kg) or saline once a week for six times. Mice were rechallenged with Con A 17 days after repeated administrations of Con A. Repeated Con A administrations elicited a sustained inhibition of rechallenged-Con A-induced liver injury. Plasma TNF-alpha and IFN-gamma levels after rechallenge of Con A were decreased compared with that of repeated saline treatments. By contrast, plasma IL-4 and IL-10 levels after rechallenge of Con A were increased. In spleen cells prepared from repeated Con A treated mice, the production of TNF-alpha and IFN-gamma 24 h after co-incubation with Con A decreased, and that of IL-4 and IL-10 increased. In naive mice, plasma ALT level after Con A injection was decreased by the transfer of spleen cells prepared from the repeated Con A treated mice. The repeated administrations of Con A elicited Th1 to Th2 cytokine shift and the tolerant state against the Con A-induced liver injury in mice. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
URI: http://ir.obihiro.ac.jp/dspace/handle/10322/61
ISSN: 1386-6346
出現コレクション:02001学術雑誌論文

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