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タイトル: Localization of alpha 1-2 Fucose Glycan in the Mouse Olfactory Pathway
著者: Kondoh, Daisuke
Kamikawa, Akihiro
Sasaki, Motoki
Kitamura, Nobuo
キーワード: alpha 1-2 Fucose
Anterior olfactory nucleus
Glycosylation
Lateral olfactory tract
Olfactory bulb
Olfactory epithelium
Olfactory tubercle
Piriform cortex
Ulex europaeus agglutinin-I
Vomeronasal epithelium
発行日: Jan-2017
出版者: Karger
誌名: Cells Tissues Organs
巻: 203
号: 1
開始ページ: 20
終了ページ: 28
抄録: Glycoconjugates in the olfactory system play critical roles in neuronal formation, and alpha 1-2 fucose (alpha 1-2Fuc) glycan mediates neurite outgrowth and synaptic plasticity. Histochemical findings of a1-2Fuc glycan in the mouse olfactory system detected using Ulex europaeus agglutinin-I (UEA-I) vary. This study histochemically assessed the main olfactory and vomeronasal pathways in male and female ICR and C57BL/6J mice aged 3-4 months using UEA-I. Ulex europaeus agglutinin-I reacted with most receptor cells arranged mainly at the basal region of the olfactory epithelium. The olfactory nerve layer and glomerular layer of the main olfactory bulb were speckled with positive UEA-I staining, and positive fibers were scattered from the glomerular to the internal plexiform layer. The lateral olfactory tract and rostral migratory stream were also positive for UEA-I. We identified superficial shortaxon cells, interneurons of the external plexiform layer, external, middle and internal tufted cells, mitral cells and granule cells as the origins of the UEA-I-positive fibers in the main olfactory bulb. The anterior olfactory nucleus, anterior piriform cortex and olfactory tubercle were negative for UEA-I. Most receptor cells in the vomeronasal epithelium and most glomeruli of the accessory olfactory bulb were positive for UEA-I. Our findings indicated that alpha 1-2Fuc glycan is located within the primary and secondary, but not the ternary, pathways of the main olfactory system, in local circuits of the main olfactory bulb and within the primary, but not secondary, pathway of the vomeronasal system. (C) 2016 S. Karger AG, Basel
URI: http://ir.obihiro.ac.jp/dspace/handle/10322/4576
DOI: info:doi/10.1159/000447009
ISSN: 1422-6405
権利情報: This is the peer-reviewed but unedited manuscript version of the following article: Cells Tissues Organs 2017;203:20-28 (DOI: 10.1159/000447009)]. The final, published version is available at http://doi.org/10.1159/000447009.
出現コレクション:01A01学術雑誌論文

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