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タイトル: Rolipram improves facilitation of contextual fear extinction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease
著者: Kinoshita, Ken-ichi
Muroi, Yoshikage
Unno, Toshihiro
Ishii, Toshiaki
キーワード: Memory extinction
MPTP-Treated mice
Phosphodiesterase IV inhibitor rolipram
発行日: May-2017
出版者: Japanese Pharmacological Society
誌名: Journal of Pharmacological Sciences
巻: 134
号: 1
開始ページ: 55
終了ページ: 58
抄録: Cognitive impairment often occurs in Parkinson's disease (PD), but the mechanism of onset remains unknown. Recently, we reported that PD model mice produced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) show facilitation of hippocampal memory extinction, which may be the cause of cognitive impairment in PD. When we examined the cAMP/CREB signaling in the hippocampus, decreased levels of cAMP and phosphorylated CREB were observed in the dentate gyrus (DG) of MPTP-treated mice. Administration of rolipram improved the memory deficits with concomitant recovery of cAMP and phosphorylated CREB levels, suggesting that reduced cAMP/CREB signaling in the DG leads to cognitive impairment in MPTP-treated mice. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.
URI: http://ir.obihiro.ac.jp/dspace/handle/10322/4547
DOI: info:doi/10.1016/j.jphs.2017.04.002
ISSN: 1347-8613
権利情報: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
出現コレクション:01A01学術雑誌論文

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