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タイトル: Towards a preventive strategy for neosporosis: Challenges and future perspectives for vaccine development against infection with Neospora caninum
著者: Nishikawa, Yoshifumi
キーワード: Adjuvant
Cattle
Neospora caninum
Neosporosis
Vaccine
発行日: 2017
出版者: Japanese Society of Veterinary Science
誌名: Journal of Veterinary Medical Science
巻: 79
号: 8
開始ページ: 1374
終了ページ: 1380
抄録: Neosporosis is caused by the intracellular protozoan parasite Neospora caninum. This major disease-causing pathogen is responsible for inducing abortion in cattle, and these adverse events occur sporadically all over the world, including Japan. Currently, there are no vaccines on the market against infection with N. caninum. Because live and attenuated vaccines against N. caninum have had safety and effectiveness issues, development of a next-generation vaccine is urgently required. To develop a vaccine against neosporosis, my laboratory has been focused on the following: 1) understanding the host immune responses against Neospora infection, 2) identifying vaccine antigens and 3) developing an effective antigen-delivery system. The research strategy taken in my laboratory will have strong potential to progress current understanding of the pathogenesis of N. caninum infection and promote development of a novel subunit vaccine based on the specific vaccine antigen with an antigen-delivery system for controlling neosporosis. c 2017 The Japanese Society of Veterinary Science.
URI: http://ir.obihiro.ac.jp/dspace/handle/10322/4544
DOI: info:doi/10.1292/jvms.17-0285
ISSN: 09167250
権利情報: This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
出現コレクション:05001学術雑誌論文

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