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タイトル: Toxoplasma gondii Infection in Mice Impairs Long-Term Fear Memory Consolidation through Dysfunction of the Cortex and Amygdala
著者: Ihara, Fumiaki
Nishimura, Maki
Muroi, Yoshikage
Mahmoud, Motamed Elsayed
Yokoyama, Naoaki
Nagamune, Kisaburo
Nishikawa, Yoshifumi
発行日: Oct-2016
出版者: American Society for Microbiology
誌名: Infection and Immunity
巻: 84
号: 10
開始ページ: 2861
終了ページ: 2870
抄録: Chronic infection with Toxoplasma gondii becomes established in tissues of the central nervous system, where parasites may directly or indirectly modulate neuronal function. Epidemiological studies have revealed that chronic infection in humans is a risk factor for developing mental diseases. However, the mechanisms underlying parasite-induced neuronal dysfunction in the brain remain unclear. Here, we examined memory associated with conditioned fear in mice and found that T. gondii infection impairs consolidation of conditioned fear memory. To examine the brain pathology induced by T. gondii infection, we analyzed the parasite load and histopathological changes. T. gondii infects all brain areas, yet the cortex exhibits more severe tissue damage than other regions. We measured neurotransmitter levels in the cortex and amygdala because these regions are involved in fear memory expression. The levels of dopamine metabolites but not those of dopamine were increased in the cortex of infected mice compared with those in the cortex of uninfected mice. In contrast, serotonin levels were decreased in the amygdala and norepinephrine levels were decreased in the cortex and amygdala of infected mice. The levels of cortical dopamine metabolites were associated with the time spent freezing in the fear-conditioning test. These results suggest that T. gondii infection affects fear memory through dysfunction of the cortex and amygdala. Our findings provide insight into the mechanisms underlying the neurological changes seen during T. gondii infection.
URI: http://ir.obihiro.ac.jp/dspace/handle/10322/4480
DOI: info:doi/10.1128/IAI.00217-16
ISSN: 0019-9567
出現コレクション:05001学術雑誌論文

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