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タイトル: High antiviral effects of hibiscus tea extract on the 115 subtypes of low and highly pathogenic avian influenza viruses
著者: Baatartsogt, Tugsbaatar
Bui, Vuong N.
Trinh, Dai Q.
Yamaguchi, Emi
Gronsang, Dulyatad
Thampaisarn, Rapeewan
Ogawa, Haruko
Imai, Kunitoshi
キーワード: antiviral effect
H5N1
herbal tea extract
hibiscus
発行日: Sep-2016
出版者: Japanese Society of Veterinary Science
誌名: Journal of Veterinary Medical Science
巻: 78
号: 9
開始ページ: 1405
終了ページ: 1411
抄録: Viral neuraminidase inhibitors are widely used as synthetic anti-influenza drugs for the prevention and treatment of influenza. However, drug-resistant influenza A virus variants, including H5N1 highly pathogenic avian influenza viruses (HPAIVs), have been reported. Therefore, the discovery of novel and effective antiviral agents is warranted. We screened the antiviral effects of 11 herbal tea extracts (hibiscus, black tea, tencha, rosehip tea, burdock tea, green tea, jasmine tea, ginger tea, lavender tea, rose tea and oak tea) against the H5N1 HPAIV in vitro. Among the tested extracts, only the hibiscus extract and its fractionated extract (frHibis) highly and rapidly reduced the titers of all H5 HPAIVs and low pathogenic AIVs (LPAIVs) used in the pre-treatment tests of Madin Darby canine kidney (MDCK) cells that were inoculated with a mixture of the virus and the extract. Immunogold electron microscopy showed that anti-H5 monoclonal antibodies could not bind to the deformed H5 virus particles pretreated with frHibis. In post-treatment tests of MDCK cells cultured in the presence of frHibis after infection with H5N1 HPAIV, the frHibis inhibited viral replication and the expression of viral antigens and genes. Among the plants tested, hibiscus showed the most prominent antiviral effects against both H5 HPAIV and LPAIV.
URI: http://ir.obihiro.ac.jp/dspace/handle/10322/4473
DOI: info:doi/10.1292/jvms.16-0124
ISSN: 0916-7250
権利情報: This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License <http://creativecommons.org/licenses/by-nc-nd/4.0/>.
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