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タイトル: Inorganic nanoparticles kill Toxoplasma gondii via changes in redox status and mitochondrial membrane potential
著者: Adeyemi, Oluyomi Stephen
Murata, Yuho
Sugi, Tatsuki
Kato, Kentaro
キーワード: antiparasite
drug screening
nanomedicine
toxoplasmosis
発行日: Feb-2017
出版者: Dove Medical Press
誌名: International Journal of Nanomedicine
巻: 12
開始ページ: 1647
終了ページ: 1661
抄録: This study evaluated the anti-Toxoplasma gondii potential of gold, silver, and platinum nanoparticles (NPs). Inorganic NPs (0.01-1,000 mu g/mL) were screened for antiparasitic activity. The NPs caused >90% inhibition of T. gondii growth with EC50 values of <= 7, <= 1, and <= 100 mu g/mL for gold, silver, and platinum NPs, respectively. The NPs showed no host cell cytotoxicity at the effective anti-T. gondii concentrations; the estimated selectivity index revealed a >= 20-fold activity toward the parasite versus the host cell. The anti-T. gondii activity of the NPs, which may be linked to redox signaling, affected the parasite mitochondrial membrane potential and parasite invasion, replication, recovery, and infectivity potential. Our results demonstrated the antiparasitic potential of NPs. The findings support the further exploration of NPs as a possible source of alternative and effective anti-T. gondii agents.
URI: http://ir.obihiro.ac.jp/dspace/handle/10322/4450
DOI: info:doi/10.2147/IJN.S122178
ISSN: 1178-2013
権利情報: This article is distributed under the terms of the Creative Commons Attribution - NonCommercial (BY-NC) 3.0 International License (http://creativecommons.org/licenses/by-nc/3.0/).
出現コレクション:05001学術雑誌論文

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