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タイトル: Overexpression of Interleukin 2 Receptor, Thymidine Kinase and Immunoglobulin-Associated Alpha-1 Messenger RNA in a Clinical Case of Enzootic Bovine Leukosis
著者: TAWFEEQ, Mohammad Monir
TAGAWA, Michihito
ITOH, Yuuki
SUGIMOTO, Kazuya
KOBAYASHI, Yoshiyasu
INOKUMA, Hisashi
古林, 与志安
猪熊, 壽
キーワード: biomarker
bovine leukosis
gene expression
発行日: 2012
出版者: 日本獣医学会
抄録: A 49-month-old Holstein cow with anorexia, tachypnea, enlarged peripheral lymph nodes, and difficulty standing up was suspected of bovine leukosis. Hematological examination revealed lymphocytosis with the presence of neoplastic cells. Increased total lactate dehydrogenase (LDH) activity, isozymes of LDH-2 and LDH-3 activities and thymidine kinase activity were observed. Cytological findings of fine needle aspiration of subiliac lymph nodes indicated lymphosarcoma. Histopathology and antibody analysis confirmed the diagnosis of enzootic bovine leukosis, a B-cell bovine lymphoma caused by bovine leukemia virus. Gene expressions known as biomarkers of hematopoietic neoplasia in human were also examined in the present case. Increased messenger RNA expression of interleukin 2 receptor, thymidine kinase, and immunoglobulin-associated alpha-1 was observed in the case animal.
URI: http://ir.obihiro.ac.jp/dspace/handle/10322/4096
ISSN: 1347-7439
0916-7250
出現コレクション:00B01学術雑誌論文

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