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このアイテムの引用には次の識別子を使用してください: http://ir.obihiro.ac.jp/dspace/handle/10322/4065

タイトル: Role of Adherent Spleen Cells in the Induction of Cytotoxic Activity by Toxoplasma Lysate Antigen
その他のタイトル: トキソブラズマ溶解抗原(TLA)によって誘導される細胞障害性における脾臓の付着性細胞の役割
著者: MIYAHARA, Kazuro
TOSE, Shinichi
SAKURAI, Haruhisa
IGARASHI, Ikuo
SAITO, Atsushi
HIROSE, Tsuneo
SUZUKI, Naoyoshi
宮原, 和郎
五十嵐, 郁男
キーワード: adherent cell
cytotoxic activity
macrophage
spleen cell
Toxoplasma lysate antigen
発行日: 1992
出版者: 日本獣医学会
誌名: Journal of Veterinary Medical Science
巻: 54
号: 4
開始ページ: 629-635
抄録: In order to identify mechanisms responsible for the anti-tumor effects of Toxoplasma lysate antigen (TLA), we used an in vitro 51Cr release assay to study the functional properties of plastic-adherent cells during induction of splenic cytotoxic activity by TLA. Cytotoxic activity of non-adherent cells was measured in all experiments after a 6 days incubation. Induction of cytotoxic non-adherent cells by TLA required the presence of plastic-adherent spleen cells. In contrast, rhIL-2 alone was able to induce transformation of cytotoxic non-adherent cells from non-adherent spleen cells. Contact between adherent and non-adherent spleen cells was necessary for successful induction of cytotoxic non-adherent cells by TLA. Treatment of spleen cells with anti-macrophage serum prevented induction of cytotoxic activity by TLA. Biologically active IL-2 was not detected in culture supernatants of spleen cells exposed to TLA. These findings suggest that contact between TLA-sensitized non-adherent cells and macrophages is necessary for induction of cytotoxic cells in the presence of TLA. This contact, however, is not necessary for generation of IL-2-induced killer cells.
URI: http://ir.obihiro.ac.jp/dspace/handle/10322/4065
ISSN: 1347-7439
0916-7250
権利情報: 日本獣医学会
出現コレクション:00B01学術雑誌論文

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