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タイトル: Lung Cytokine Gene Expression is Correlated with Increased Severity of Disease in a Novel H4N8 Influenza Virus Isolated from Shorebirds.
著者: ARAI, Yasuha
N. BUI, Vuong
TAKEDA, Yohei
Q. TRINH, Dai
NIBUNO, Sayo
RUNSTADLER, Jonathan
OGAWA, Haruko
IMAI, Kunitoshi
小川, 晴子
キーワード: avian influenza virus
cytokine
H4N8
mouse
pathogenicity
発行日: 2013
出版者: 日本獣医学会
誌名: Journal of Veterinary Medical Science
巻: 75
号: 10
開始ページ: 1341-1347
抄録: The lung cytokine gene expression profiles of mice infected with 2 strains of H4N8 viruses isolated from shorebirds and reference H4 viruses from ducks are compared. Major differences between the two H4N8 strains of shorebirds, one of which causes a severe respiratory disease in mice, are in the PB1 and NS1 genes. In mice with H4N8 virus induced pneumonia, overall expression of TNF-α, IL-6 and IL-12 genes was markedly higher than in mice infected with other H4 viruses tested, although gene expression of type I interferon was not increased until day 4 post viral infection. In contrast, in mice infected with a comparison H4N8 strain, gene expression of type I interferon peaked on day 1 post viral infection. Overall, the cytokine response corresponds with the severity of disease caused by shorebird H4N8 virus. The results obtained in this study provide valuable information to understand the immunopathology induced by a low pathogenic avian influenza virus, which may be useful in preparation for outbreaks of novel influenza A virus.
URI: http://ir.obihiro.ac.jp/dspace/handle/10322/4061
ISSN: 1347-7439
0916-7250
出現コレクション:07001学術雑誌論文

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