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タイトル: Expression of Amphiregulin During the Pre- and Post-implantation Period in the Mouse Reproductive Tract
著者: LEE, Dong-Soo
YANAGIMOTO UETA, Yoshiko
SUZUKI, Hiroshi
鈴木, 宏志
キーワード: Mice
Implantation
Embryo transfer
Amphiregulin
mRNA
発行日: 2006
出版者: 日本繁殖生物学会
誌名: Journal of Reproduction and Development
巻: 52
号: 6
開始ページ: 781-787
抄録: In mammals, embryo implantation is an essential step in reproduction. Implantation is a phenomenon that involves crosstalk between the blastocyst and the maternal endometrium. However, the molecular basis of the connections between the blastocyst and endometrium is not yet fully understood. Amphiregulin is a member of the epidermal growth factor family and is known to be expressed in the luminal epithelium of the mouse uterus on 3.5 days post coitum (dpc). Thus, to clarify the mechanism of amphiregulin at fetomaternal interface, we analyzed the expression pattern of amphiregulin mRNA in the oviducts and uteri of pregnant and psuedopregnant mice by means of real-time PCR. Amphiregulin expression in the pregnant uterus dramatically increased on 2.5 dpc, peaked on 3.5 dpc, and declined by 5.5 dpc. Furthermore, to analyze the effect of the presence of an embryo on amphiregulin expression, we determined the expression pattern of amphiregulin mRNA in the uterus after embryo transfer on 0.5 and 1.5 dpc. A previous study showed that the expression of amphiregulin mRNA depends on the concentration of progesterone. However, our present results indicate that amphiregulin mRNA is upregulated by the presence of fertilized eggs in the lumen of the oviduct on 0.5 dpc.
URI: http://ir.obihiro.ac.jp/dspace/handle/10322/3026
ISSN: 1348-4400
0916-8818
権利情報: 日本繁殖生物学会
出現コレクション:05001学術雑誌論文

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