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タイトル: Potato Pulps Lowered the Serum Cholesterol and Triglyceride Levels in Rats
著者: HASHIMOTO, Naoto
ITO, Yusaku
HAN, Kyu-Ho
SHIMADA, Ken-ichiro
SEKIKAWA, Mitsuo
TOPPING, David L.
BIRD, Anthony R.
NODA, Takahiro
CHIJI, Hideyuki
FUKUSHIMA, Michihiro
韓, 圭鎬
島田, 謙一郎
関川, 三男
福島, 道広
キーワード: cholesterol
triglyceride
potato pulps
liver
発行日: 2006
出版者: 学会誌刊行センター
抄録: In our previous study, we demonstrated that retrograded starch, a kind of resistant starch, of beans reduced serum lipid levels in rats. In this study, we examined whether retrograded starch in potato pulps could reduce serum lipid concentrations. Rats were given diets containing 15 g of retrograded starch in potato pulps from the Benimaru potato (BM) or Hokkaikogane potato (HK) in a 100 g diet for 4 wk. At the 4th week, the total cholesterol level in the serum in the BM group and serum triglyceride (TG) level in the HK group were significantly lower than those in the control group. In the BM group, the contents of fecal bile acids were significantly higher than those in the control group. On the other hand, in the HK group, the hepatic mRNA level of fatty acid synthase (FAS) was significantly lower than that in the control group. The FAS mRNA level correlated with the mRNA level of sterol regulatory element-binding protein-1c (SREBP-1c), a regulator of expression of FAS, positively. These results suggested that BM pulp promoted the excretion of bile acids, which resulted in a low concentration of serum cholesterol. On the other hand, HK pulp inhibited the synthesis of fatty acids at the mRNA levels of FAS and SREBP-1c, which might lead to a reduction of the serum TG level.
記述: 日本ビタミン学会、日本栄養・食糧学会共同編集
URI: http://ir.obihiro.ac.jp/dspace/handle/10322/2910
ISSN: 18817742
03014800
出現コレクション:00E01学術雑誌論文

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