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タイトル: Tartary Buckwheat Sprout Powder Lowers Plasma Cholesterol Level in Rats
著者: KUWABARA, Tomoko
HAN, Kyu-Ho
HASHIMOTO, Naoto
YAMAUCHI, Hiroaki
SHIMADA, Ken-ichiro
SEKIKAWA, Mitsuo
FUKUSHIMA, Michihiro
島田, 謙一郎
関川, 三男
福島, 道広
韓, 圭鎬
キーワード: bile acid
buckwheat sprout powder
hepatic mRNAs
serum cholesterol
short-chain fatty acid
発行日: 2007
出版者: 学会誌刊行センター
抄録: We examined the effects of different types of buckwheat sprouts on the plasma cholesterol concentration, fecal steroid excretion and hepatic mRNA expression related to cholesterol metabolism in rats. Rats were fed a cholesterol-free diet with 5 g of Kitawasesoba common buckwheat sprout powder (KS)/100 g, 5 g of Hokkai T no. 8 tartary buckwheat sprout powder (HS-8)/100 g or 5 g of Hokkai T no. 9 tartary buckwheat sprout powder (HS-9)/100 g of diet for 4 wk. Control rats were fed a diet with α-cornstarch instead of sprout powder for 4 wk. There were no significant differences in food intake, body weight, liver weight or cecal contents among the groups. Plasma total cholesterol concentrations in the HS-8 and HS-9 groups were significantly lower than in the control group, whereas there was no significant difference between the KS and control groups. Fecal bile acid excretion and cecal short-chain fatty acid concentrations in the KS, HS-8 and HS-9 groups were significantly greater than in the control group. Furthermore, fecal matter excretion in the KS, HS-8 and HS-9 groups tended to be increased compared to the control group, with that in the HS-8 group being significantly higher than in the control group. Hepatic cholesterol 7α-hydroxylase mRNA expression in the KS, HS-8 and HS-9 groups and hepatic HMG-CoA reductase mRNA expression in the HS-9 group were significantly higher than in the control group. The results suggest that tartary buckwheat sprout powder has a serum cholesterol-lowering function by enhancing fecal bile acid excretion through increased fecal matter excretion or the upregulation of hepatic cholesterol 7α-hydroxylase mRNA expression in rats.
記述: 日本ビタミン学会、日本栄養・食糧学会共同編集
URI: http://ir.obihiro.ac.jp/dspace/handle/10322/2909
ISSN: 18817742
03014800
出現コレクション:00E01学術雑誌論文

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