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タイトル: Preliminary studies on the effects of orally-administered Transforming Growth Factor-beta on protozoan diseases in mice
著者: Namangala, Boniface
Inoue, Noboru
Sugimoto, Chihiro
井上, 昇
キーワード: low-dose
mice
orally-delivered TGF-β1
protection
protozoan parasites
発行日: Aug-2009
出版者: Graduate School of Veterinary Medicine, Hokkaido University
誌名: Japanese Journal of Veterinary Research
巻: 57
号: 2
開始ページ: 101-108
抄録: Transforming growth factor beta-1 (TGF-β1) is a pleiotropic cytokine with both pro- and antiinflammatory properties, depending on its environment and concentration. The present study evaluated the effects of orally-delivered TGF-β1 on mice parenterally-infected with various protozoan parasites. We report that while orally-administered TGF-β1 seems to confer partial protection against murine chronic babesiosis and acute trypanosomosis, no beneficial clinical effects were observed against acute babesiosis, malaria or toxoplasmosis. Taken together, these preliminary data suggest that the systemic effects conferred by exogenous TGF-β1 could be parasite speciesspecific. The variations in different parasitic infections could be due to (i) intrinsic differences between parasite species and/or strains in their ability to induce production of immunosuppressive molecules and/or (ii) differences in mechanisms governing host protection against different parasitic infections.
URI: http://ir.obihiro.ac.jp/dspace/handle/10322/2716
ISSN: 00471917
出現コレクション:05003学術研究報告(紀要)

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