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タイトル: Effect of Oligomannose-Coated Liposome-Based Vaccine on Rodent Babesiosis
著者: Ishigame, T
Takabatake, N
Iseki, H
Ota, N
Koyama, A
Igarashi, I
Nishikawa, Y
Ikehara, Y
Kojima, N
Yokoyama, N
五十嵐, 郁男
西川, 義文
横山, 直明
キーワード: Oligomannose-coated liposomes (OML)
Vaccine
Babesiosis
Babesia rodhaini
Babesia microti
P0
発行日: Jun-2009
出版者: National Research Center for Protozoan Diseases
誌名: The Journal of protozoology research
巻: 19
号: 1
開始ページ: 10-23
抄録: Oligomannose-coated liposome (OML)-based vaccines have been reported to induce Th1-based immunity against entrapped antigens in immunized animals and to show protective effects against several protozoal diseases. In the present study, we produced a recombinant Babesia rodhaini ribosomal phosphoprotein P0 (rBrP0) that showed immunological cross reactivity with another rodent Babesia parasite, B. microti. We evaluated the efficacy of vaccination with OML-entrapped rBrP0 on B. rodhaini and B. microti infections in mice. Prior immunization with the OML-based rBrP0 vaccine, or with a Freund’s adjuvant-based rBrP0 vaccine, failed to demonstrate any protective effect against lethal infection with B. rodhaini, but the OML-based vaccine did induce protective immunity against B. microti infection, based on a reduction in peak parasitemia levels and prompt clearance of the parasite, compared with control mice. OML might be an effective adjuvant for future vaccines aimed at the control of severe domestic babesioses.
URI: http://ir.obihiro.ac.jp/dspace/handle/10322/2383
ISSN: 09174427
出現コレクション:05001学術雑誌論文

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