帯広畜産大学 学術情報リポジトリ >
050原虫病研究センター >
05001学術雑誌論文 >

このアイテムの引用には次の識別子を使用してください: http://ir.obihiro.ac.jp/dspace/handle/10322/132

タイトル: Determination of serum isometamidium levels in sheep and goats under field conditions using isometamidium-ELISA
著者: Wesongah, J. O.
Murilla, G. A.
Kibugu, J. K.
Jones, T. W.
キーワード: Isometamidium chloride
ELISA
Sheep
Goats
Trypanosomosis
発行日: Oct-2000
出版者: National Research Center for Protozoan Diseases
誌名: The Journal of Protozoology Research
巻: 10
4
開始ページ: 191-201
抄録: Twenty eight sheep and 28 goats were treated with isometamidium chloride (Samorin®, hone Merieux, Lyon, France) at a dose of 1 mg/kg body weight (bw) by intramuscular injection. All the animals were grazed in a tsetse-infested area. They were monitored for anaemia, body weight, anti-trypanosome antibodies and serum isometamidium concentration using the isometamidium enzyme-linked immunosorbent assay (ELISA) for more than 80 days after treatment. Serum isometamidium levels were higher in goats than in sheep throughout the experimental period. Isometamidium was still detectable in sheep and goats for up to 77 and 98 days, respectively, alter treatment (detection limit=0.1 ng/ml). The isometamidium elimination half-lives in sheep and goats were approximately 13.8 and 17.4 days, respectively. No trypanosomes were detected in either the isometamidium-treated or untreated control animals. The present study demonstrated that the isometamidium-ELISA, originally developed for use in cattle, may be equally useful in monitoring the drug in sheep and goats. The elimination half-lives and serum isometamidium levels were markedly higher in goats than in sheep. This could have important implications for chemoprophylaxis in small ruminants under field conditions.
URI: http://ir.obihiro.ac.jp/dspace/handle/10322/132
ISSN: 0917-4427
出現コレクション:05001学術雑誌論文

このアイテムのファイル:

ファイル 記述 サイズフォーマット
Prot.Vol.10-4-4.pdf201.68 kBAdobe PDF見る/開く

このリポジトリに保管されているアイテムはすべて著作権により保護されています。

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2006 MIT and Hewlett-Packard - ご意見をお寄せください