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タイトル: Toxoplasma gondii: DNA vaccination with genes encoding antigens MIC2, M2AP, AMA1 and BAG1 and evaluation of their immunogenic potential
著者: Dautu, George
Munyaka, Biscah
Carmen, Gabriella
Zhang, Guohong
Omata, Yoshitaka
Xuan, Xuenan
Igarashi, Makoto
キーワード: Toxoplasma gondii
DNA
deoxyribonucleic acid
DNA immunization
MIC2
microneme protein-2
M2AP
MIC2 associated protein
AMA1
apical membrane antigen-1
BAG1
bradyzoite antigen-1
IgG
immunoglobulin G
発行日: Jul-2007
出版者: Elsevier
誌名: Experimental Parasitology
巻: 116
号: 3
開始ページ: 273-282
抄録: A combination of antigenic regions of microneme proteins have been previously reported as being protective against chronic toxoplasmosis. In this work, we evaluated immune responses induced by immunizing BALB/c and C57BL/6 mice intradermally with plasmid DNA encoding the protein sequences of Toxoplasma gondii AMA1, MIC2, M2AP and BAG1. Mice immunized with the AMA1 gene developed high levels of serum IgG2a and c antibodies as well as cellular immune responses associated with IFN-γ synthesis suggesting a modulated Th1 type of response. Immunization with the AMA1 gene resulted in a partial but significant protection against the acute phase of toxoplasmosis compared to MIC2, M2AP and BAG1 genes. Therefore, the AMA1 gene appears to generate a strong specific immune response and also provides effective protection against toxoplasmosis more than the MIC2, M2AP and BAG1 genes.
URI: http://ir.obihiro.ac.jp/dspace/handle/10322/1031
出現コレクション:05001学術雑誌論文

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